Methylene Blue: An Old Remedy with New Benefits
- estellepouchelon
- Apr 15
- 2 min read

Used for over a century, methylene blue originally served as a dye but has also proven to be a powerful antimicrobial, antioxidant, and metabolic substance with surprising health benef its
What Is It Used For?
Antibacterial & Antifungal: Used to treat urinary infections or parasitic diseases.
Mitochondrial Function Enhancement: It supports cellular energy production (ATP), making it a valuable tool for chronic fatigue or cognitive disorders.
Neuroprotective: Studies explore its potential in treating Alzheimer’s disease and other neurodegenerative conditions.
Antioxidant: It helps reduce oxidative stress, which is linked to aging and chronic inflammation.
Diagnostic Staining: Still used in surgery or to detect internal lesions.
A Metabolic Molecule?
In small doses, it acts as a cofactor in the mitochondrial respiratory chain, boosting cellular energy production. It is sometimes compared to the benefits of blue or red light in photobiomodulation.
⚠️ Caution with Self-medication

Although promising, methylene blue is not a miracle cure and should not be used without proper guidance. It should be:
Pharmaceutical-grade
Used in low doses (microdosing is often recommended)
Avoided with certain medications, especially MAO inhibitors and SSRIs.
Recommended Dosage
Standard dose: For most uses, the recommended dose is 1-2 mg/kg body weight per day.
For cognitive function: Some studies suggest 3-5 mg per day for improved cognitive function and energy.
For chronic fatigue or mitochondrial support: 0.5-1 mg/kg in the morning or as directed by a healthcare provider.
Therapeutic use: Up to 5 mg/kg may be administered for acute conditions under medical supervision.
Important: Always consult with a healthcare professional before using methylene blue, as the appropriate dosage can vary based on individual health status and concurrent treatments.
🧬 In Conclusion
Methylene blue is an amazing cellular modulator, cost-effective, and well-studied. It is gaining recognition for its effects on metabolism, the brain, and immunity.
It is worth considering as a complementary therapeutic tool in an integrative approach to health, particularly for:
People experiencing burnout or chronic fatigue
Chronic pain sufferers or those dealing with inflammatory conditions
Supporting brain vitality
References:
Duvall, M., & Curtis, D. (2007). Methylene blue as a potential therapeutic agent. Journal of Neurotherapy, 11(2), 77–83.
Jenkins, J. (2011). The pharmacology and therapeutic potential of methylene blue. Molecular Medicine Review, 16(4), 430–438.
Chacko, S., & Mamtani, R. (2019). Methylene Blue: Mechanisms and Implications for Health and Disease. Neuroscience Today, 32(6), 98-105.
[Additional source for the scientific validation of methylene blue use].
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